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小鼠抗人 Anti-TRAIL Antibody 

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小鼠抗人 Anti-TRAIL Antibody

产品编号 包装 货期 市场价 您的价格 节省 数量 购买
C86-H104-09-MM-50 µL 50 µL 现货 1180.00 1180.00 0
C86-H104-09-MM-100 µL 100 µL 现货 2080.00 2080.00 0
C86-H104-09-MM-200 µL 200 µL 现货 2980.00 2980.00 0
C86-H104-09-MM-1 mL 1 mL 现货 12090.00 12090.00 0
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产品名称:小鼠抗人 Anti-TRAIL Antibody

GENERAL INFORMATION

Product name:Anti-TRAIL Antibody
Validated applications:ELISA,ELISA(Cap)
Species reactivity Reacts with: Human
Specificity:Human TRAIL
Immunogen:Recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) Protein 


Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) (rh TNFSF10 / TRAIL / APO-2L (CD253); Catalog#10409-HNAE; NP_003801.1; Val114-Gly281). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.


Source:Monoclonal Mouse IgG1 Clone #03
Purification:Protein A
Formulation:0.2 μm filtered solution in PBS
Conjugate:Unconjugated
Form:Liquid


Shipping:This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.


Anti-TRAIL Antibody (Mouse Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000  
ELISA(Cap)

1:250-1:2000



Anti-TRAIL Antibody Alternative Names

Anti-Apo-2L Antibody;Anti-APO2L Antibody;Anti-CD253 Antibody;Anti-TL2 Antibody;Anti-TRAIL Antibody

TRAIL Background Information
Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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